Publications

Intervacc´s collaborators have published and participated in a number of doctoral thesis works and peer reviewed scientific journals with good ranking. Here is a list of relevant publications:

Referee- reviewed articles in international papers

CategoryPublicationYear
VASIP early trialsSow vaccination with a novel recombinant protein vaccine protects piglets against Streptococcus suis infection. Vaccine 53, Sara Frosth, David Reddick, Francesco Righetti, Joakim Bjerketorp, Karin Jacobsson, Birgitta Henriques-Normark, Magdalena Jacobson,Bengt Guss, Tim Wood, Lars Frykberg,Jan-Ingmar Flock and Andrew Waller.2025
Research StranglesConservation of vaccine antigen sequences encoded by sequenced strains of Streptococcus equi subsp. equi, Equine Veterinary Journal 55 issue 1, 92-101, Sara Frosth, Ellen Ruth A. Morris, Hayley Wilson, Lars Frykberg, Karin Jacobsson, Julian Parkhill, Jan-Ingmar Flock, Tim Wood, Bengt Guss, David M. Aanensen, Ashley G. Boyle, Miia Riihimäki, Noah D. Cohen, Andrew S. Waller2023
Strangvac clinical trialsIntramuscular vaccination with Strangvac is safe and induces protection against equine strangles caused by Streptococcus equi, Vaccine 38, 4861-4868 , Carl Robinson, Andrew S. Waller, Lars Frykberg, Margareta Flock, Olof Zachrisson, Bengt Guss and Jan-Ingmar Flock.2020
Strangvac early trialsGetting to grips with strangles: an effective multi-component recombinant vaccine for the protection of horses from Streptococcus equi infection. PLoS Pathogen. Published 18 sep 2009, doi: 10.1371/journal.ppat.1000584, Bengt Guss, Margareta Flock, Lars Frykberg, Andrew S. Waller, Carl Robinson, Ken C. Smith, and Jan-Ingmar Flock. 2009
Strangvac early trialsStrangvac: A recombinant fusion protein vaccine that protects against strangles, caused by Streptococcus equi Vaccine, 2018 Mar 7;36(11):1484-1490, Robinson, C., Frykberg, L., Flock, M., Guss, B., Waller, A., Flock, J-I 2017
Strangvac early trialsProtective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse. Vaccine 24:4144-4151. Flock, M., Karlström, Å., Lannergård, J., Guss, B. and Flock, J.-I. 2006
Strangvac early trialsVaccination of horses against strangles using recombinant antigens from Streptococcus equi. Vaccine 25:3629-3635. Waller, A., Flock, M., Smith, K., Robinson, C., Mitchell, Z., Karlström, A., Lannergård, J., Bergman, R., Guss, B. and Flock JI2007
Strangvac early trialsRecombinant Streptococcus equi proteins protect mice in challenge experiments and induce immune response in horses. Infect Immun. 72:3228-3236. Flock, M., Jacobsson, K., Hirst, T., R., Franklin, A., Guss, B., and Flock, J.-I. 2004
Strangvac targetsThe streptococcal collagen-binding protein CNE specifically interferes with alphaVbeta3-mediated cellular interactions with triple helical collagen. J Biol Chem 285: 35803-35813. van Wieringen T, Kalamajski S, Lidén A, Bihan D, Guss B, Heinegård D, Farndale RW and Rubin K.2010
Strangvac targetsIdentification of a novel collagen-like protein, SclC, in Streptococcus equi using signal phage display.Vet Microbiol 104:179-188. Karlström, Å., Jacobsson, K., Flock, M., Flock,J.-I., and Guss B.2004
Strangvac targetsSclC is a member of a novel family of collagen-like proteins in Streptococcus equi subspecies equi that are recognized by antibodies against SclC. Vet Microbiol 114:72-8. Karlström, Å., Jacobsson, K. and Guss, B. 2006
Strangvac targetsIdeE, an IgG-endopeptidase of Streptococcus equi ssp equi. FEMS Microbiology Letters 262:230-235. Lannergård, J. and Guss, B. 2006
Strangvac targets CNE, a collagen-binding protein of Streptococcus equi. FEMS Microbiol. Lett. 222:69-74. Lannergård, J., Frykberg, L. and Guss, B.2003
Strangvac targetsShot-gun phage display mapping of two streptococcal cell-surface proteins. Microbiol Res.152:1-8. Jacobsson, K., Jonsson, H., Lindmark, H., Guss, B., Lindberg, M. and Frykberg. L. 1997
Strangvac targetsA protein G related cell surface protein in Streptococcus zooepidemicus. Infect Immun 63:2968-2975. Jonsson, H., Lindmark, H. and Guss. B. 1995
Research StranglesNovel seM-types of Streptococcus equi subsp. equi identified in isolates circulating in Argentina Equine Vet J. Carla P Bustos, Alejandra J Muñoz, Nora Guida, Andrew Waller, María Mesplet.2022
Research StranglesSurveillance of strangles in UK horses between 2015 and 2019 based on laboratory detection of Streptococcus equi. Vet Rec Dec;189(12):e948, DOI: 10.1002/vetr.948. Abigail McGlennon, Andrew Waller, Kristien Verheyen, Josh Slater, John Grewar, David Aanensen, Richard Newton.2021
Research StranglesStreptococcus equi infections: current best practice in the diagnosis and management of ‘strangles’. UK-Vet EquineVol. 5, No. Sup2 David Rendle, Nic de Brauwere, Gayle Hallowell, Philip Ivens, Abigail McGlennon, Richard Newton, Jo White, Andrew Waller.2021
Research StranglesGlobetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses Microb Genom. Catriona Mitchell, Karen F Steward, Amelia R L Charbonneau, Saoirse Walsh, Hayley Wilson, John F Timoney, Ulli Wernery, Marina Joseph, David Craig, Kees van Maanen, Annelies Hoogkamer-van Gennep, Albertine Leon, Lucjan Witkowski, Magdalena Rzewuska, Ilona Stefańska, Monika Żychska, Gunther van Loon, Ray Cursons, Olivia Patty, Els Acke, James R Gilkerson, Charles El-Hage, Joanne Allen, Hiroshi Bannai, Yuta Kinoshita, Hidekazu Niwa, Teótimo Becú, John Pringle, Bengt Guss, Reinhard Böse, Yvonne Abbott, Lisa Katz, Bernadette Leggett, Tom C Buckley, Shlomo E Blum, Fátima Cruz López, Ana Fernández Ros, Maria Cristina Marotti Campi, Silvia Preziuso, Carl Robinson, J Richard Newton, Ellen Schofield, Ben Brooke, Mike Boursnell, Nicolas de Brauwere, Roxane Kirton, Charlotte K Barton, Khalil Abudahab, Ben Taylor, Corin A Yeats, Richard Goater, David M Aanensen, Simon R Harris, Julian Parkhill, Matthew T G Holden, Andrew Waller.2021
Research StranglesHorses vaccinated with live attenuated intranasal strangles vaccine seroconvert to SEQ2190 and SeM Equine Vet J, Ashley G Boyle, Catriona Mitchell, Darko Stefanovski, Andrew S Waller. 2021
Research StranglesSeroprevalence of Streptococcus equi subspecies equi in Croatia - Short communication Acta Vet Hung, Zrinka Štritof, Catriona Mitchell, Nenad Turk, Josipa Habuš, Suzana Hađina, Matko Perharić, Andrew S Waller.2021
Research StranglesAntiphagocytic Function of an IgG Glycosyl Hydrolase from Streptococcus equi subsp. equi and Its Use as a Vaccine Component, Infection and Immunity 80 No. 8, Margareta Flock, Lars Frykberg, Markus Sköld, Bengt Guss, Jan-Ingmar Flock2012
Research StranglesInfection of mast cells with live streptococci causes a toll-like receptor 2- and cell-cell contact-dependent cytokine and chemokine response. Infect Immun. 78:854-864. Rönnberg E, Guss B and Pejler G. 2010
Research StranglesTwo novel IgG endopeptidases of Streptococcus equi, FEMS Microbiology Letters vol 298, p 44-50, Greta Hulting, Margareta Flock, Lars Frykberg, Jonas Lannergård, Jan-Ingmar Flock, Bengt Guss2009
Research StranglesA secreted collagen- and fibronectin-binding streptococcal protein modulates cell-mediated collagen gel contraction and interstitial fluid pressure. J Biol Chem 283:1234-1242. Lidén., A., van Wieringen, T., Lannergård, J., Kassner, A., Heinegård, D., Reed, R.K., Guss, B. and Rubin, K. 2008
Research StranglesA fibronectin-binding protein from Streptococcus equi binds collagen and modulates cell-mediated collagen gel contraction. Biochem Biophys Res Com 340:604-610. Lidén, Å., Karlström, Å., Lannergård, J., Kalamajski, S., Guss, B., Rubin, K. and Rydén, C. 2006
Research StranglesStudies of fibronectin-binding proteins in Streptococcus equi. Infect Immun 73:7243-7251. Lannergård, J., Flock, M., Johansson, S., Flock, J.-I., and Guss, B. 2005
Research StranglesFNE belongs to a novel family of fibronectin-binding and collagen-binding proteins of Streptococcus equi subspecies equi (manuscript in Jonas Lannergårds doctoral thesis, SLU ISBN 91-576-7129-X). Lannergård, J. and Guss, B 2006
Research StranglesComparison of the fibronectin-binding protein FNE from Streptococcus equi subspecies equi with FNZ from S. equi subspecies zooepidemicus reveals a major and conserved difference. Infect Immun. 69: 3159-3163. Lindmark, H., Nilsson, M. and Guss, B. 2001
Research StranglesSFS, a novel fibronectin-binding protein from Streptococcus equi, inhibits the binding between fibronectin and collagen. Infect. Immun. 67: 2383-2388. Lindmark, H. and Guss, B. 1999
Research StranglesPulsed-field gel electrophoresis and distribution of the genes zag and fnz in isolates of Streptococcus equi. Res Vet Sci. 66:93-99. Lindmark, H., Jonsson, P., Olsson-Engvall, E. and Guss, B. 1999
Research StranglesFibronectin-binding protein of Streptococcus equi subspecies zooepidemicus. Infect Immun 64: 3993-3999. Lindmark, H., Jacobsson, K., Frykberg, L. and Guss, B. 1996
Research streptococcalFunctional Insights into the High-Molecular-Mass Penicillin-Binding Proteins of Streptococcus agalactiae Revealed by Gene Deletion and Transposon Mutagenesis Analysis. J Bacteriol, Luchang Zhu, Prasanti Yerramilli, Layne Pruitt, Abhishek Mishra, Randall Olsen, Stephen B Beres, Andrew Waller, James Musser. 2021

Avhandlingar

1”Characterization of adhesive extracellular proteins from Streptococcus equi”. Doctoral thesis, Swedish University of Agricultural Sciences. Hans Lindmark (1999) ISSN 1401-6249
ISBN 91-576-5488-3
2“Development of a vaccine against strangles”. Karolinska Institutet, Margareta Flock (2005) ISBN 91-7140-500-3
3“Collage-like proteins in horse pathogenic Stretococcus equi”. Doctoral thesis, Swedish University of Agricultural Sciences, Åsa Karlström (2005)ISSN 1652-6880
ISBN 91-576-6998-8
4“Potentially virulence-related extracellular proteins of Streptococcus equi”. Doctoral thesis, Swedish University of Agricultural Sciences, Jonas Lannergård (2006) ISSN 1652-6880
ISBN 91-576-7129-X